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Unlike therapies such as human chorionic gonadotropin (hCG) or clomiphene citrate, which stimulate the testes to produce more testosterone, PT-141 does not trigger luteinizing hormone (LH) or follicle-stimulating hormone (FSH), which are the pituitary hormones responsible for signaling the testes

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Intestinal extracts were then shown to potentiate insulin secretion in dogs and this led to the discovery of two primary gut hormones with incretin activity, gastric inhibitory peptide (GIP) and glucagon like peptide-1 (GLP-1) (10, 15, 18, 28, 75)

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